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Cotard syndrome in anti-NMDAR encephalitis: two patients and insights from molecular imaging
- Source :
- Neurocase. 27:64-71
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Cotard syndrome is a clinical condition defined by the presence of nihilistic delusions. We report two patients with Cotard syndrome in whom anti-NMDAR encephalitis (ANMDARE) was confirmed. Both cases showed features of affective psychosis, developed catatonic syndrome, and worsened after the use of antipsychotics. 18F-FDG PET brain studies showed a bilateral hemispheric pattern of hypometabolism in posterior regions, mainly in the cingulate cortex and in the medial aspects of parietal and occipital lobes. A more severe hypometabolism was observed in the right hemisphere of both patients. Both cases remitted with the use of specific immunotherapy for ANMDARE.
- Subjects :
- Pathology
medicine.medical_specialty
Cotard syndrome
Delusions
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
Arts and Humanities (miscellaneous)
Fluorodeoxyglucose F18
medicine
Humans
0501 psychology and cognitive sciences
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Autoimmune encephalitis
business.industry
05 social sciences
Nihilistic delusions
Anti-NMDAR Encephalitis
medicine.disease
Molecular Imaging
nervous system
Positron-Emission Tomography
Neurology (clinical)
business
030217 neurology & neurosurgery
Encephalitis
Subjects
Details
- ISSN :
- 14653656 and 13554794
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Neurocase
- Accession number :
- edsair.doi.dedup.....7eaae058e2bc34e83e5177923d88e976