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Serocorrelates of protection against infant group B streptococcus disease
- Publication Year :
- 2019
- Publisher :
- Elsevier: Lancet, 2019.
-
Abstract
- Group B streptococcus (GBS) is a leading cause of young infant mortality and morbidity globally, with vaccines being developed for over four decades but none licensed to date. A serocorrelate of protection against invasive disease in young infants is being considered to facilitate vaccine early licensure, followed by demonstration of efficacy assessed postlicensure. In this Review, we synthesise the available scientific evidence to define an immune correlate associated with GBS disease risk reduction on the basis of studies of natural infection. We summarise studies that have investigated GBS serum anticapsular or anti-protein antibodies, and studies measuring the association between antibody function and disease risk reduction. We highlight how knowledge on the development of correlates of protection from existing vaccines could be harnessed to facilitate GBS vaccine development. These lessons include aggregation of serocorrelates of protection for individual serotypes, understanding the relationship between immunity derived from natural exposure of adults and vaccine-induced immunity, or using extrapolation of protection from in-vitro immunoassay results. We also highlight key considerations for the assessment of the role of antibodies to derive a serocorrelate of risk reduction in future seroepidemiological studies of GBS disease.
- Subjects :
- 0301 basic medicine
Serotype
030106 microbiology
Mothers
Disease
medicine.disease_cause
Group B
Infant, Newborn, Diseases
Streptococcus agalactiae
03 medical and health sciences
0302 clinical medicine
Immune system
Immunity
Streptococcal Infections
Medicine
Humans
030212 general & internal medicine
biology
business.industry
Streptococcus
Streptococcal Vaccines
Infant, Newborn
Antibodies, Bacterial
Infant mortality
Infectious Diseases
Immunology
Carrier State
biology.protein
Female
Antibody
business
Subjects
Details
- Language :
- English
- ISSN :
- 14733099
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7ebf9e704427f2ee92ce5b86667a09fc