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Three-component ruthenium-catalyzed remote C-H functionalization of 8-aminoquinoline amides
- Source :
- Chemical communications (Cambridge, England). 56(84)
- Publication Year :
- 2020
-
Abstract
- Multicomponent reactions can efficiently construct complex molecular structures from simple precursors. Herein, a novel ruthenium-catalyzed three-component highly selective remote C-H functionalization of 8-aminoquinoline amides has been described. The reaction tolerates a wide range of functional groups, producing arylation/difluoroalkylation products of olefins with potential biological activity and pharmaceutical value. Radical scavenging and radical clock experiments show that a free radical process is involved and a H/D exchange experiment suggests that the reaction might involve ortho-C-H activation of the aromatic ring. A possible mechanism is proposed.
- Subjects :
- 8-Aminoquinoline
Chemistry
Metals and Alloys
chemistry.chemical_element
Biological activity
General Chemistry
Ring (chemistry)
Combinatorial chemistry
Catalysis
Free Radical Process
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ruthenium
chemistry.chemical_compound
Radical clock
Materials Chemistry
Ceramics and Composites
Surface modification
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 56
- Issue :
- 84
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....7ec0bfef18f354b9cef2b133adee6f9d