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Decidual NK Cells Alter In Vitro First Trimester Extravillous Cytotrophoblast Migration: A Role for IFN-γ
- Source :
- The Journal of Immunology. 177:8522-8530
- Publication Year :
- 2006
- Publisher :
- The American Association of Immunologists, 2006.
-
Abstract
- Abnormal placentation results in either inadequate (consequences: recurrent miscarriage, intrauterine growth restriction, and preeclampsia) or overzealous (consequences: placenta accreta, increta, and percreta) placentation. NK cells dominate in first trimester decidua and probably control extravillous cytotrophoblast (EVT) invasion. We examined this interaction in a novel way, using NK cells and villous explants from concordant first trimester pregnancies cocultured using a new collagen (two-dimensional) model of placentation. Decidual NK (dNK) cells exerted contact-independent inhibition of normal cytotrophoblast migration, associated with changes in the cytotrophoblast expression of metalloproteases-2 and -9, and plasminogen activator inhibitor-1. dNK cells did not affect EVT proliferation and apoptosis, and cell column formation. dNK cell effects were partially reversed by neutralizing Abs against IFN-γ. We provide ex vivo human evidence of a direct role for dNK in modulating EVT differentiation as they form columns and then migrate from anchoring villi.
- Subjects :
- Adult
Cell signaling
Placenta
Immunology
Cell
Cell Communication
Biology
Andrology
Interferon-gamma
Cell Movement
Pregnancy
medicine
Humans
Immunology and Allergy
Cells, Cultured
reproductive and urinary physiology
Cytotrophoblast
Decidua
Placentation
Coculture Techniques
Trophoblasts
Killer Cells, Natural
Pregnancy Trimester, First
medicine.anatomical_structure
Matrix Metalloproteinase 9
Apoptosis
embryonic structures
Matrix Metalloproteinase 2
Female
Plasminogen activator
Ex vivo
Subjects
Details
- ISSN :
- 15506606 and 00221767
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- The Journal of Immunology
- Accession number :
- edsair.doi.dedup.....7ed245fe432d95d41da3029457814131