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Systemic Delivery and Biodistribution of Cisplatin in Vivo
- Source :
- Molecular Pharmaceutics. 13:2677-2682
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin’s off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.
- Subjects :
- 0301 basic medicine
Biodistribution
medicine.medical_treatment
Pharmaceutical Science
Antineoplastic Agents
Pharmacology
Article
Nephrotoxicity
03 medical and health sciences
0302 clinical medicine
Ototoxicity
In vivo
Neoplasms
Drug Discovery
medicine
Animals
Humans
Distribution (pharmacology)
Cisplatin
Chemotherapy
Dose-Response Relationship, Drug
Chemistry
medicine.disease
3. Good health
030104 developmental biology
030220 oncology & carcinogenesis
Systemic administration
Molecular Medicine
medicine.drug
Subjects
Details
- ISSN :
- 15438392 and 15438384
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Molecular Pharmaceutics
- Accession number :
- edsair.doi.dedup.....7ee4d68c9d68674efd8e116b8b7c50a4