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Cynomolgus macaque IL37 polymorphism and control of SIV infection
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019), Scientific Reports, Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-44235-x⟩, Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.7981. ⟨10.1038/s41598-019-44235-x⟩, Scientific Reports, 2019, 9 (1), pp.7981. ⟨10.1038/s41598-019-44235-x⟩
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- The association between gene polymorphisms and plasma virus load at the set point (SP-PVL) was investigated in Mauritian macaques inoculated with SIV. Among 44 macaques inoculated with 50 AID50, six individuals were selected: three with SP-PVL among the highest and three with SP-PVL among the lowest. The exons of 390 candidate genes of these six animals were sequenced. Twelve non-synonymous single nucleotide polymorphisms (NS-SNPs) lying in nine genes potentially associated with PVL were genotyped in 23 animals. Three NS-SNPs with probabilities of association with PVL less than 0.05 were genotyped in a total of 44 animals. One NS-SNP lying in exon 1 of the IL37 gene displayed a significant association (p = 3.33 × 10−4) and a strong odds ratio (19.52). Multiple linear regression modeling revealed three significant predictors of SP-PVL, including the IL37 exon 1 NS-SNP (p = 0.0004) and the MHC Class IB haplotypes M2 (p = 0.0007) and M6 (p = 0.0013). These three factors in conjunction explained 48% of the PVL variance (p = 4.8 × 10−6). The potential role of IL37 in the control of SIV infection is discussed.
- Subjects :
- MESH: Histocompatibility Antigens Class I / immunology
Male
0301 basic medicine
Candidate gene
[SDV]Life Sciences [q-bio]
Simian Acquired Immunodeficiency Syndrome
Gene Expression
lcsh:Medicine
MESH: Base Sequence
MESH: Linear Models
Exon
0302 clinical medicine
Polymorphism (computer science)
Gene expression
Odds Ratio
MESH: Animals
lcsh:Science
MESH: High-Throughput Nucleotide Sequencing
ComputingMilieux_MISCELLANEOUS
Multidisciplinary
MESH: Host-Pathogen Interactions / immunology
High-Throughput Nucleotide Sequencing
Exons
Viral Load
MESH: Interleukin-1 / genetics
3. Good health
MESH: Histocompatibility Antigens Class I / genetics
MESH: Interferon-Stimulated Gene Factor 3, gamma Subunit / immunology
Host-Pathogen Interactions
[SDV.IMM]Life Sciences [q-bio]/Immunology
Simian Immunodeficiency Virus
MESH: Interleukin-1 / immunology
HIV infections
MESH: Host-Pathogen Interactions / genetics
MESH: Gene Expression
Single-nucleotide polymorphism
Biology
MESH: Genetic Loci
Polymorphism, Single Nucleotide
MESH: Interferon-Stimulated Gene Factor 3, gamma Subunit / genetics
Article
03 medical and health sciences
Immunogenetics
Animals
Gene
Base Sequence
Histocompatibility Antigens Class I
Haplotype
lcsh:R
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology
MESH: Haplotypes
Odds ratio
Virology
Interferon-Stimulated Gene Factor 3, gamma Subunit
Macaca fascicularis
030104 developmental biology
Haplotypes
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
Genetic Loci
Linear Models
lcsh:Q
MESH: Exons
Sequence Alignment
030217 neurology & neurosurgery
Interleukin-1
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....7f10cd764ad05ff00d00a2e63ad53fe4