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GLP-1 Receptor agonists and diabetic kidney disease: A call of attention to nephrologists
- Source :
- Biblos-e Archivo: Repositorio Institucional de la UAM, Universidad Autónoma de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 947, p 947 (2020), Dipòsit Digital de la UB, Universidad de Barcelona, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Publication Year :
- 2020
- Publisher :
- MDPI, Basel, SMwitzerland, 2020.
-
Abstract
- Type 2 diabetes mellitus (T2DM) represents the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESKD), and diabetic kidney disease (DKD) is a major cause of morbidity and mortality in diabetes. Despite advances in the nephroprotective treatment of T2DM, DKD remains the most common complication, driving the need for renal replacement therapies (RRT) worldwide, and its incidence is increasing. Until recently, prevention of DKD progression was based around strict blood pressure (BP) control, using renin–angiotensin system blockers that simultaneously reduce BP and proteinuria, adequate glycemic control and control of cardiovascular risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RA) are a new class of anti-hyperglycemic drugs shown to improve cardiovascular and renal events in DKD. In this regard, GLP-1RA o er the potential for adequate glycemic control in multiple stages of DKD without an increased risk of hypoglycemia, preventing the onset of macroalbuminuria and slowing the decline of glomerular filtration rate (GFR) in diabetic patients, also bringing additional benefit in weight reduction, cardiovascular and other kidney outcomes. Results from ongoing trials are pending to assess the impact of GLP-1RA treatments on primary kidney endpoints in DKD
- Subjects :
- medicine.medical_specialty
Medicina
Renal function
lcsh:Medicine
030209 endocrinology & metabolism
Review
030204 cardiovascular system & hematology
Hypoglycemia
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
Chronic kidney disease
Medicine
Malalties cròniques
Diabetic kidney disease
Glycemic
Kidney
Proteinuria
Kidney diseases
business.industry
lcsh:R
Type 2 Diabetes Mellitus
General Medicine
medicine.disease
diabetic kidney disease
medicine.anatomical_structure
Chronic diseases
Malalties del ronyó
medicine.symptom
business
GLP-1
chronic kidney disease
Kidney disease
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Biblos-e Archivo: Repositorio Institucional de la UAM, Universidad Autónoma de Madrid, Biblos-e Archivo. Repositorio Institucional de la UAM, instname, Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 947, p 947 (2020), Dipòsit Digital de la UB, Universidad de Barcelona, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona
- Accession number :
- edsair.doi.dedup.....7f133c489d4ef13641e8437cbd95beb0