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Uncovering Clinical Features of De Novo Philadelphia Positive Myelodysplasia
- Source :
- Case Reports in Hematology, Case Reports in Hematology, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi Publishing Corporation, 2017.
-
Abstract
- Myelodysplastic syndrome (MDS) is cytogenetically heterogeneous and retains variable risk for acute myeloid leukemia transformation. Though not yet fully understood, there is an association between genetic abnormalities and defects in gene expression. The functional role for infrequent cytogenetic alteration remains unclear. An uncommon chromosomic abnormality is the presence of the Philadelphia (Ph) chromosome. Here, we report a patient with Ph+ MDS treated with low dose Dasatinib who achieved hematologic response for 7 months. In addition, we also examined the English literature on all de novo Ph + MDS cases between 1996 and 2015 to gain insight into clinical features and outcome.
- Subjects :
- Oncology
Functional role
medicine.medical_specialty
Pathology
business.industry
lcsh:RC633-647.5
Low dose
Myeloid leukemia
Philadelphia positive
Chromosome
Case Report
General Medicine
lcsh:Diseases of the blood and blood-forming organs
Hematologic Response
Dasatinib
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
hemic and lymphatic diseases
medicine
Abnormality
business
030215 immunology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20906579 and 20906560
- Volume :
- 2017
- Database :
- OpenAIRE
- Journal :
- Case Reports in Hematology
- Accession number :
- edsair.doi.dedup.....7f19eecdf1f18cc6d6786f3e33a2c6f6