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The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis
- Source :
- Journal of Molecular Neuroscience. 66:617-628
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease that affects motor neurons and leads to death within 2 to 3 years after the first symptoms manifest. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression in fundamental cellular processes and, post-transcriptionally, the translation levels of target mRNA transcripts. We searched PubMed for studies that examined miRNAs in ALS patients and attempted to group the results in order to find the strongest miRNA candidate for servings as an ALS biomarker. The studies on humans so far have been diverse, yielding considerably heterogeneous results, as they were performed on a wide variety of tissues and subjects. Among the miRNAs that were found consistently deregulated are miR-206, miR-133, miR-149, and miR-338-3p. Additively, the deregulation of some specific miRNAs seems to compose a miRNA expression profile that is specific for ALS. More research is required in order for the scientific community to reach a consensus.
- Subjects :
- 0301 basic medicine
Amyotrophic Lateral Sclerosis
Neurodegeneration
Translation (biology)
General Medicine
Disease
Biology
medicine.disease
Bioinformatics
Biomarker (cell)
MicroRNAs
03 medical and health sciences
Cellular and Molecular Neuroscience
030104 developmental biology
0302 clinical medicine
Gene expression
microRNA
medicine
Humans
Epigenetics
Amyotrophic lateral sclerosis
Biomarkers
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15591166 and 08958696
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Neuroscience
- Accession number :
- edsair.doi.dedup.....7f23ab421fc4536852f61b6bfef242d9