Back to Search
Start Over
MicroTools enables automated quantification of capillary density and red blood cell velocity in handheld vital microscopy
- Source :
- Communications Biology, 2(1):217. Springer Nature, Communications Biology, Communications Biology, Vol 2, Iss 1, Pp 1-15 (2019), Communications Biology, 2:217. Springer Nature
- Publication Year :
- 2019
-
Abstract
- Direct assessment of capillary perfusion has been prioritized in hemodynamic management of critically ill patients in addition to optimizing blood flow on the global scale. Sublingual handheld vital microscopy has enabled online acquisition of moving image sequences of the microcirculation, including the flow of individual red blood cells in the capillary network. However, due to inherent content complexity, manual image sequence analysis remained gold standard, introducing inter-observer variability and precluding real-time image analysis for clinical therapy guidance. Here we introduce an advanced computer vision algorithm for instantaneous analysis and quantification of morphometric and kinetic information related to capillary blood flow in the sublingual microcirculation. We evaluated this technique in a porcine model of septic shock and resuscitation and cardiac surgery patients. This development is of high clinical relevance because it enables implementation of point-of-care goal-directed resuscitation procedures based on correction of microcirculatory perfusion in critically ill and perioperative patients.<br />Matthias Hilty et al. develop MicroTools, a computer vision algorithm that analyzes image sequences obtained from handheld vital microscopy. MicroTools can provide morphometric and kinetic information about the sublingual microcirculation in real-time, making this tool highly relevant in clinical settings.
- Subjects :
- Resuscitation
Erythrocytes
Swine
Critical Illness
Point-of-Care Systems
ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION
Medicine (miscellaneous)
Hemodynamics
610 Medicine & health
Image processing
1100 General Agricultural and Biological Sciences
Article
General Biochemistry, Genetics and Molecular Biology
Microcirculation
1300 General Biochemistry, Genetics and Molecular Biology
Image Processing, Computer-Assisted
Computational models
Animals
Humans
Medicine
lcsh:QH301-705.5
Microscopy, Video
business.industry
Septic shock
2701 Medicine (miscellaneous)
Gold standard (test)
Blood flow
Translational research
medicine.disease
Shock, Septic
Cardiovascular biology
Capillaries
Red blood cell
medicine.anatomical_structure
lcsh:Biology (General)
10023 Institute of Intensive Care Medicine
General Agricultural and Biological Sciences
business
Algorithms
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 23993642
- Volume :
- 2
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....7f24ddd258e9d5b6cb2d2f0321a19e3a