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Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe
- Source :
- Journal of Clinical Pathology, Journal Of Clinical Pathology, r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (IGTP), r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, Universidad de Alicante (UA)
- Publication Year :
- 2021
-
Abstract
- AimsLung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak.MethodsFifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time.ResultsIn most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing.ConclusionsThe workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
biomarkers, lung neoplasms, molecular, molecular biology, pathology, tumour
Disease
lung neoplasms
medicine.disease_cause
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
molecular biology
molecular
biomarkers
pathology
tumour
Liquid biopsy
Lung cancer
Original Research
Coronavirus
business.industry
Molecular pathology
Outbreak
Workload
General Medicine
medicine.disease
lung neoplasm
030104 developmental biology
030220 oncology & carcinogenesis
Concomitant
biomarker
business
Subjects
Details
- Language :
- English
- ISSN :
- 00219746
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Pathology, Journal Of Clinical Pathology, r-IGTP: Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (IGTP), r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol, Universidad de Alicante (UA)
- Accession number :
- edsair.doi.dedup.....7f37400b73f8c4b71de7201e4369a434