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Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes
- Source :
- Organic letters. 23(6)
- Publication Year :
- 2021
-
Abstract
- A highly regioselective copper-catalyzed 1,4-chloro- and bromotrifluoromethylation of 1,3-enynes has been presented for the first time, which affords an efficient transformation to access halo- and CF3-containing tetrasubstituted allene derivatives with good to excellent yield. This protocol is practical and convenient, in which a wide range of functional groups are compatible. Applications of this method for the gram-scale preparation and late-stage functionalization of biologically active molecules are also demonstrated.
Details
- ISSN :
- 15237052
- Volume :
- 23
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....7f38c3a92cafbdb4ed36c1b5ba461511