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Liver histopathology in COVID-19 patients: A mono-Institutional series of liver biopsies and autopsy specimens
- Source :
- Pathology, Research and Practice
- Publication Year :
- 2021
- Publisher :
- Elsevier GmbH, 2021.
-
Abstract
- Few studies have focused on COVID-19 patients' hepatic histopathological features. Many of the described morphological landscapes are non-specific and possibly due to other comorbidities or to Sars-CoV-2-related therapies. We describe the hepatic histopathological findings of 3 liver biopsies obtained from living COVID-19 patients in which active SARS-CoV-2 infection was molecularly confirmed and biopsied because of significant alterations of liver function tests and 25 livers analyzed during COVID-19-related autopsies. Main histopathological findings were (i) the absence of significant biliary tree or vascular damages, (ii) mild/absent lymphocytic hepatitis; (iii) activation of (pigmented) Kupffer cells, (iv) hepatocellular regenerative changes, (v) the presence of steatosis, (vi) sinusoidal ectasia, micro-thrombosis and acinar atrophy in autopsy specimens No viral particle actively infecting the hepatic or endothelial cells was detected at in situ hybridization. The morphological features observed within the hepatic parenchyma are not specific and should be considered as the result of an indirect insult resulting from the viral infection or the adopted therapeutic protocols.
- Subjects :
- 0301 basic medicine
Male
Pathology
medicine.medical_specialty
COVID19
Biopsy
Autopsy
In situ hybridization
Article
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Atrophy
Ectasia
medicine
80 and over
Humans
Aged
Aged, 80 and over
Hepatitis
medicine.diagnostic_test
business.industry
SARS-CoV-2
Liver Diseases
COVID-19
Cell Biology
Middle Aged
medicine.disease
030104 developmental biology
Liver
030220 oncology & carcinogenesis
Female
Steatosis
Liver function tests
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Pathology, Research and Practice
- Accession number :
- edsair.doi.dedup.....7f652dd2bd28aca837f0be1a208e57c2