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Initial Experience with 64Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms: Comparison with Analog PET
- Source :
- Diagnostics, Vol 11, Iss 350, p 350 (2021), Diagnostics, Loft, M, Johnbeck, C B, Carlsen, E A, Johannesen, H H, Oturai, P, Langer, S W, Knigge, U & Kjaer, A 2021, ' Initial Experience with 64 Cu-DOTATATE Digital PET of Patients with Neuroendocrine Neoplasms : Comparison with Analog PET ', Diagnostics, vol. 11, no. 2, 350 . https://doi.org/10.3390/diagnostics11020350, Volume 11, Issue 2
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The recent introduction of solid-state detectors in clinical positron emission tomography (PET) scanners has significantly improved image quality and spatial resolution and shortened acquisition time compared to conventional analog PET scanners. In an initial evaluation of the performance of our newly acquired Siemens Biograph Vision 600 PET/CT (digital PET/CT) scanner for 64Cu-DOTATATE imaging, we compared PET/CT acquisitions from patients with neuroendocrine neoplasms (NENs) grades 1 and 2 and stable disease on CT who were scanned on both our Siemens Biograph 128 mCT PET/CT (analog PET/CT) and digital PET/CT within 6 months as part of their routine clinical management. Five patients fulfilled the criteria and were included in the analysis. The digital PET acquisition time was less than 1/3 of the analog PET acquisition time (digital PET, mean (min:s): 08:20 (range, 07:59–09:45)<br />analog PET, 25:28 (24:39–28:44), p &lt<br />0.001). All 44 lesions detected on the analog PET with corresponding structural correlates on the CT were also found on the digital PET performed 137 (107–176) days later. Our initial findings suggest that digital 64Cu-DOTATATE PET can successfully be performed in patients with NENs using an image acquisition time of only 1/3 of what is used for an analog 64Cu-DOTATATE PET.
- Subjects :
- PET/CT
Image quality
Clinical Biochemistry
solid-state detector
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
64Cu-DOTATATE
0302 clinical medicine
somatostatin receptor imaging
medicine
Image acquisition
In patient
lcsh:R5-920
PET-CT
neuroendocrine neoplasms
medicine.diagnostic_test
digital PET
business.industry
NEN
Solid state detector
3. Good health
NET
Positron emission tomography
030220 oncology & carcinogenesis
Pet scanner
Acquisition time
lcsh:Medicine (General)
Nuclear medicine
business
Subjects
Details
- ISSN :
- 20754418
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....7f662ba2c9fdd2aae67d3bbe75c765aa