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Coagulation and fibrinolytic parameters in normal pregnancy and in pregnancy complicated by intrauterine growth retardation
Coagulation and fibrinolytic parameters in normal pregnancy and in pregnancy complicated by intrauterine growth retardation
- Source :
- Europe PubMed Central, Scopus-Elsevier
- Publication Year :
- 1998
-
Abstract
- The objective of this article is to evaluate the plasma levels of coagulation and fibrinolysis parameters in the third trimester of gestation and 72 hr postdelivery. Antithrombin III (ATIII), thrombin-antithrombin III complexes (TAT), heparin cofactor II (HCII), protein C (PC), protein S (PS), tissue plasminogen activator (t-PA), D-dimer, and plasminogen activator inhibitors (PAI-1 and PAI-2) levels in uncomplicated pregnancies and in pregnancies complicated by intrauterine growth retardation (IUGR) have been determined. Normal pregnant women (n = 63) and women whose was complicated by IUGR (n = 10) formed the study population. Coagulation and fibrinolysis parameters were estimated using commercial tests. There were no differences in ATIII, HCII, and PS levels between normal and IUGR pregnancies. TAT, t-PA, and D-dimer levels were higher in IUGR pregnancy than in the uncomplicated pregnancy group. PAI-1 and PAI-2 were found depressed in IUGR pregnancy when compared with normal pregnancy. Changes in coagulation and fibrinolytic systems occur in plasma of women with pregnancies complicated by IUGR. The results suggest an activation of the coagulation system in pregnancies complicated by IUGR. Reduced PAI-2 and high TAT levels correlate with birth weight. In IUGR pregnancies a hypercoagulative state with hyperfibrinolytic compensatory mechanisms is suggested.
- Subjects :
- Adult
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
medicine.medical_treatment
Pregnancy Trimester, Third
Antithrombin III
Tissue plasminogen activator
Protein S
Cohort Studies
Pregnancy
Internal medicine
Blood plasma
Fibrinolysis
Plasminogen Activator Inhibitor 1
medicine
Plasminogen Activator Inhibitor 2
Birth Weight
Humans
reproductive and urinary physiology
Heparin cofactor II
Fetal Growth Retardation
biology
business.industry
Antithrombin
Thrombin
Obstetrics and Gynecology
medicine.disease
female genital diseases and pregnancy complications
Blood Coagulation Factors
Pregnancy Complications
Endocrinology
Tissue Plasminogen Activator
Pediatrics, Perinatology and Child Health
biology.protein
Heparin Cofactor II
Linear Models
Gestation
Female
business
medicine.drug
Protein C
Subjects
Details
- ISSN :
- 07351631
- Volume :
- 15
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American journal of perinatology
- Accession number :
- edsair.doi.dedup.....7f8146022499ae3505617a9efd92f2b8