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Thailandepsin A
- Source :
- Acta Crystallographica Section E, Vol 67, Iss 11, Pp o2948-o2949 (2011), Acta Crystallographica Section E: Structure Reports
- Publication Year :
- 2011
- Publisher :
- International Union of Crystallography, 2011.
-
Abstract
- Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl]-5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H37N3O6S3, is a newly reported [Wang et al. (2011). J. Nat. Prod. doi:10.1021/np200324x] bicyclic depsipeptide that has potent histone deacetylase inhibitory activity and broad-spectrum antiproliferative activity. The absolute configuration of thailandepsin A has been determined from the anomalous dispersion and the stereochemistry of all chiral C atoms. Intramolecular N—H...O and N—H...S hydrogen bonds occur. Intermolecular N—H...O and O—H...O hydrogen bonds are observed in the crystal structure.
Details
- Language :
- English
- ISSN :
- 16005368
- Volume :
- 67
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Acta Crystallographica Section E
- Accession number :
- edsair.doi.dedup.....7f910de513308b09f9988f746dc8d1e5