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Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells
- Source :
- BMC Pharmacology & Toxicology, BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activated receptor-delta (PPARδ) agonists was shown in previous studies. PPARδ agonists also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells. Methods In this study, the individual and synergic anti-inflammatory effects of GLP-1 receptor (exendin-4) and PPARδ (L-165,041) agonists in AGE-treated rat mesangial cells (RMC) were investigated. Results The results showed both exendin-4 and L-165,041 significantly attenuated AGE-induced IL-6 and TNF-α production, RAGE expression, and cell death in RMC. Similar anti-inflammatory potency was seen between 0.3 nM exendin-4 and 1 μM L-165,041. Synergic effect of exendin-4 and L-165,041 was shown in inhibiting cytokines production, but not in inhibiting RAGE expression or cell death. Conclusions These results suggest that both GLP-1 receptor and PPARδ agonists have anti-inflammatory effect on AGE-treated rat mesangial cells.
- Subjects :
- 0301 basic medicine
Glycation End Products, Advanced
endocrine system
medicine.medical_specialty
Programmed cell death
Cell Survival
Glucagon-like peptide
Anti-Inflammatory Agents
Inflammation
Diabetic nephropathy
030204 cardiovascular system & hematology
Biology
Glucagon
Phenoxyacetates
Rage
Antioxidants
Glucagon-Like Peptide-1 Receptor
RAGE (receptor)
03 medical and health sciences
0302 clinical medicine
Glycation
lcsh:RA1190-1270
Internal medicine
medicine
Animals
Pharmacology (medical)
PPAR delta
Receptor
Cells, Cultured
lcsh:Toxicology. Poisons
Pharmacology
Mesangial cell
Interleukin-6
Tumor Necrosis Factor-alpha
Venoms
lcsh:RM1-950
digestive, oral, and skin physiology
Rats
030104 developmental biology
Endocrinology
lcsh:Therapeutics. Pharmacology
Mesangial Cells
Exenatide
Peroxisome proliferator-activated receptor delta
medicine.symptom
Peptides
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20506511
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Pharmacology & Toxicology
- Accession number :
- edsair.doi.dedup.....7f9182d62bc7067bd513b68d3393f78b