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Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
- Source :
- Cell Reports, Vol 17, Iss 2, Pp 399-412 (2016), Cell reports
- Publication Year :
- 2016
- Publisher :
- Elsevier, 2016.
-
Abstract
- Summary The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4+ T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells. Type I IFN-dependent, parasite-specific IL-10 production was also observed in P. falciparum malaria patients in the field following chemoprophylaxis. Parasite-induced IL-10 suppressed inflammatory cytokine production, and IL-10 levels after drug treatment were positively associated with parasite burdens before anti-parasitic drug administration. These findings have important implications for understanding the development of host immune responses following blood-stage P. falciparum infection, and they identify type I IFNs and related signaling pathways as potential targets for therapies or vaccine efficacy improvement.
- Subjects :
- 0301 basic medicine
CD4-Positive T-Lymphocytes
medicine.medical_treatment
T cell
Plasmodium falciparum
malaria
Biology
General Biochemistry, Genetics and Molecular Biology
Article
Host-Parasite Interactions
03 medical and health sciences
Interferon-gamma
0302 clinical medicine
Immune system
CD4+ T cells
Immunity
Th1 cells
medicine
Humans
Malaria, Falciparum
lcsh:QH301-705.5
Innate immune system
Antiparasitic Agents
immune regulation
Tr1 cells
Vaccine efficacy
biology.organism_classification
Virology
Healthy Volunteers
Immunity, Innate
3. Good health
Interleukin-10
030104 developmental biology
Cytokine
medicine.anatomical_structure
type I interferons
lcsh:Biology (General)
Chemoprophylaxis
Immunology
Interferon Type I
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 22111247
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell Reports
- Accession number :
- edsair.doi.dedup.....7f99776f17dfd7ca0b6cbf88d5b3438c