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Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders
- Source :
- European Archives of Psychiatry and Clinical Neuroscience
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE: The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes. METHOD: A total of 400 inpatients from an ongoing multi-centre, follow-up program who fulfilled ICD-10 criteria for schizophrenic disorders (F2) were assessed at admission to and discharge from hospital using the Positive and Negative Syndrome Scale (PANSS). RESULTS: At admission, first episode patients (n = 121) showed higher levels of positive symptoms (PANSS positive subscore) and lower ones of negative symptoms (PANSS negative subscore) than multiple episode patients (n = 279), whereas the global disease severity (PANSS total score) was comparable. Analyses of covariance revealed that treatment response (adjusted symptom levels at discharge) was more favorable in first-episode patients, with respect to both positive and negative symptoms. CONCLUSION: The results are compatible with the hypothesis that treatment response becomes less favorable during the course of schizophrenic illness. This finding might be associated with progressive neurobiological alterations. peerReviewed
- Subjects :
- PANSS
Adult
Male
Treatment response
medicine.medical_specialty
Multiple episode
03 medical and health sciences
0302 clinical medicine
multiple episode
Recurrence
Schizophrenic Psychology
medicine
Humans
Pharmacology (medical)
Psychiatry
Social Behavior
first episode
schizophrenic disorders
treatment response
Schizophrenic disorders
Biological Psychiatry
First episode
Psychiatric Status Rating Scales
Original Paper
Psychopathology
General Medicine
Length of Stay
medicine.disease
3. Good health
030227 psychiatry
Hospitalization
Psychiatry and Mental health
Treatment Outcome
Schizophrenia
Psychiatric status rating scales
Female
Psychology
030217 neurology & neurosurgery
Antipsychotic Agents
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....7fafb5aa5af0b0e42bf7f53584669b68