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CD15, CD30, and PAX5 evaluation in Hodgkin's lymphoma on fine-needle aspiration cytology samples
- Publication Year :
- 2020
-
Abstract
- Background The phenotypical identification of diagnostic cells is crucial for the diagnosis of Hodgkin's lymphoma (HL) on fine-needle aspiration cytology (FNAC). The aim of this study is to evaluate the immunocytochemical (ICC) expression of CD30, CD15, and PAX5 in Hodgkin's cells (HC) and Reed-Sternberg cells (RSC) on smears and cell-blocks (CB) of HL and to compare the performance of each antibody on smears and CB. Methods In 21 FNAC cases of histologically confirmed classical HL, ICC identification of HC and RSC was performed using CD15, CD30, and PAX5 on smears and CB, respectively. Results CD30 was positive in 19/21 cases (90.5%; 11/11 smears and 8/10 CB), CD15 was positive in 14/21 cases (66.7%; 5/11 smears and 9/10 CB), and PAX5 was positive in 13/21 cases (61.9%; 9/11 smears and 4/10CB). Conclusions CD15, CD30, and PAX5 are useful to the FNAC identification of HC and RSC. CD30 is the most sensitive, followed by CD15 and PAX5, which are more effective on CB and smears, respectively.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Histology
CD30
Biopsy, Fine-Needle
Ki-1 Antigen
Lewis X Antigen
030209 endocrinology & metabolism
CD15
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
immune system diseases
Fine needle aspiration cytology
hemic and lymphatic diseases
Biomarkers, Tumor
Medicine
Humans
Aged
Retrospective Studies
Aged, 80 and over
PAX5
biology
business.industry
PAX5 Transcription Factor
General Medicine
Middle Aged
medicine.disease
Hodgkin's lymphoma
Hodgkin Disease
Aspiration cytology
Lymphoma
Neoplasm Proteins
fine-needle aspiration cytology
030220 oncology & carcinogenesis
biology.protein
Female
Antibody
business
Hodgkin lymphoma
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....7fbe3111eb340f2c3b4611a3acef21de