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1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT7 receptor ligands
- Source :
- Bioorganic & Medicinal Chemistry Letters. 12:2451-2454
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.
- Subjects :
- Indoles
Bicyclic molecule
Ligand
Stereochemistry
Chemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
Ligands
Biochemistry
Chemical synthesis
In vitro
5-HT7 receptor
Structure-Activity Relationship
Receptors, Serotonin
Drug Discovery
Humans
Molecular Medicine
Structure–activity relationship
Serotonin Antagonists
Selectivity
Receptor
Molecular Biology
Protein Binding
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....7fc4a58a20664c8ac571e84262d2dac4