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Impact of <scp>mind‐body</scp> treatment interventions on quality of life in neurofibromatosis patients: A systematic review and <scp>meta‐analysis</scp>
- Source :
- Dermatologic Therapy. 34
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Individuals with neurofibromatosis (NF) experience poorer quality of life (QoL), in part contributed by the clinical manifestations of NF, such as functional disability, chronic pain, and altered physical appearance. Mind-body therapies (MBTs) tailored to NF have been developed, and have demonstrated promising potential to improve QoL in this population. We sought to systematically review current evidence on the effectiveness of MBTs in addressing QoL deficits in NF patients. Databases were reviewed between the date of inception and June 2020, using search terms: neurofibromatosis, schwannomatosis, psychotherapy, mind-body, mindfulness, meditation, resiliency, and behavioral therapy. Quality appraisal was assessed using the Cochrane Risk of Bias Tools and National Institutes of Health Study Quality Assessment Tools. We conducted a meta-analysis of mean differences and reported aggregate effect estimates with 95% confidence intervals. A total of 10 articles, including randomized-controlled trials and pre-post studies, were identified. Meta-analytic results of randomized-controlled trial data from six citations demonstrated MBTs were associated with improved physical (MD = 13.63, 95%CI 6.95-20.30, P < .0001, I2 = 24%), psychological (MD = 14.11, 95%CI 6.44-21.78, P = .0003, I2 = 38%), social (MD = 9.63, 95%CI 2.93-16.33, P = .005, I2 = 0%), and environmental QoL (MD = 14.14, 95%CI 8.28-20.00, P < .00001. I2 = 0%) in NF patients. These associations were maintained at 6-months follow-up for physical, psychological, and environmental QoL (P < .05). Our findings suggest that NF-adapted MBT strategies are associated with improving QoL in diverse NF populations, including NF2 patients experiencing deafness and youth NF patients. Providers and caregivers for NF should be aware of the potential benefits of MBT in chronic NF management.
- Subjects :
- medicine.medical_specialty
Mindfulness
Adolescent
Neurofibromatoses
Population
Dermatology
Human physical appearance
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Quality of life
Internal medicine
medicine
Humans
Neurofibromatosis
education
Schwannomatosis
education.field_of_study
Mind-Body Therapies
business.industry
Chronic pain
General Medicine
medicine.disease
030220 oncology & carcinogenesis
Meta-analysis
Quality of Life
business
Neurilemmoma
Subjects
Details
- ISSN :
- 15298019 and 13960296
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Dermatologic Therapy
- Accession number :
- edsair.doi.dedup.....7feb586bd70e51953febf81649ba308f