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Effect of low-zinc status and essential fatty acids deficiency on the activities of aspartate aminotransferase and alanine aminotransferase in liver and serum of albino rats
Effect of low-zinc status and essential fatty acids deficiency on the activities of aspartate aminotransferase and alanine aminotransferase in liver and serum of albino rats
- Source :
- Die Nahrung. 48(2)
- Publication Year :
- 2004
-
Abstract
- The effects of dietary deficiencies of zinc and essential fatty acids (EFAs) or both on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were investigated in young growing rats. Four groups of albino rats were fed diets deficient in either EFA (4% hydrogenated coconut oil) or zinc (6 ppm) or both. The control diet was adequate in EFA (4% soybean oil) and zinc (100 ppm). The feeding trial lasted eight weeks and the activities of AST and ALT were determined in the liver and serum. EFA deficiency had no significant (p > 0.05) effect on liver AST. However, zinc and the double deficiencies depressed AST activity in the organ. Deficiencies of EFA, zinc and their combination depressed ALT activity in the liver significantly (p < 0.05) with a concomitant increase recorded in the serum. The data suggested alteration in endothelial permeability of the plasma membrane and thus leakage of membrane constituents in the tissue studied. It is therefore considered that these deficient diets may affect liver tissue negatively in view of the role of these enzymes in amino acid metabolism.
- Subjects :
- medicine.medical_specialty
food.ingredient
Efa deficiency
chemistry.chemical_element
Nutritional Status
Zinc
Biology
digestive system
Soybean oil
Random Allocation
food
Liver tissue
Internal medicine
medicine
Animals
Aspartate Aminotransferases
Alanine aminotransferase
Amino Acids
Alanine
chemistry.chemical_classification
Fatty Acids, Essential
food and beverages
Alanine Transaminase
medicine.disease
digestive system diseases
Rats
Endocrinology
Enzyme
chemistry
Liver
Zinc deficiency
Female
Food Science
Subjects
Details
- ISSN :
- 0027769X
- Volume :
- 48
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Die Nahrung
- Accession number :
- edsair.doi.dedup.....7ff67765e0f414434576a39909334478