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Dynamic catch-bonding generates the large stall forces of cytoplasmic dynein
- Source :
- Phys Biol
- Publication Year :
- 2020
- Publisher :
- IOP Publishing, 2020.
-
Abstract
- Cytoplasmic dynein is an important molecular motor involved in the transport of vesicular and macromolecular cargo along microtubules in cells, often in conjunction with kinesin motors. Dynein is larger and more complex than kinesin and the mechanism and regulation of its movement is currently the subject of intense research. While it was believed for a long time that dynein motors are relatively weak in terms of the force they can generate, recent studies have shown that interactions with regulatory proteins confer large stall forces comparable to those of kinesin. This paper reports on a theoretical study which suggests that these large stall forces may be the result of an emergent, ATP dependent, bistability resulting in a dynamic catch-bonding behavior that can cause the motor to switch between high and low load-force states.
- Subjects :
- Cytoplasmic Dyneins
Cytoplasmic dynein
Physics
0303 health sciences
Bistability
Dynein
Biophysics
Stall (fluid mechanics)
macromolecular substances
Cell Biology
Models, Biological
Article
Kinetics
03 medical and health sciences
Adenosine Triphosphate
0302 clinical medicine
Structural Biology
Microtubule
Molecular motor
Kinesin
Molecular Biology
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 14783975
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Physical Biology
- Accession number :
- edsair.doi.dedup.....7ff9e4b07e7ed30399996b56d379e944