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Amphotericin B Tamed by Salicylic Acid
- Source :
- ACS omega. 7(17)
- Publication Year :
- 2021
-
Abstract
- Although Amphotericin B (AmB) is considered as the "gold standard" treatment for deep fungal infections, owing to its excellent antifungal effect, it often causes severe hemolytic toxicity and nephrotoxicity, which limits its clinical use. We designed and synthesized AmB derivatives by attaching salicylic acid (SA) to the carboxyl group and confirmed their structures using
- Subjects :
- General Chemical Engineering
General Chemistry
Subjects
Details
- ISSN :
- 24701343
- Volume :
- 7
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- ACS omega
- Accession number :
- edsair.doi.dedup.....8011ccbb813306f06962a99889f1b3ce