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Amphotericin B Tamed by Salicylic Acid

Authors :
Yuming Yu
Peng Chen
Ming Gao
Wei Lan
Shijun Sun
Ziwei Ma
Rome Sultani
Yincang Cui
Muhammad Naveed Umar
Sher Wali Khan
Xiaodong Cai
Zhenjiang Liang
Hui Tan
Source :
ACS omega. 7(17)
Publication Year :
2021

Abstract

Although Amphotericin B (AmB) is considered as the "gold standard" treatment for deep fungal infections, owing to its excellent antifungal effect, it often causes severe hemolytic toxicity and nephrotoxicity, which limits its clinical use. We designed and synthesized AmB derivatives by attaching salicylic acid (SA) to the carboxyl group and confirmed their structures using

Details

ISSN :
24701343
Volume :
7
Issue :
17
Database :
OpenAIRE
Journal :
ACS omega
Accession number :
edsair.doi.dedup.....8011ccbb813306f06962a99889f1b3ce