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Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy
- Source :
- Journal of Cellular Physiology. 226:573-578
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Schnurri (Shn)-2 is a transcriptional modulator of bone formation and bone resorption and its deficiency causes low turnover state with higher cancellous bone mass due to the defects in osteoclasts that exceeds the defects in osteoblasts in mice. We addressed whether such low turnover of bone remodeling in Shn2 deficiency may be modulated in the absence of estrogen that induces high turnover state in vivo. Ovariectomy reduced bone mass in wild type compared to sham operated control mice and such reduction in bone mass was also observed in Shn2 deficient mice. However, due to the high levels of basal bone mass in Shn2 deficient mice, the bone mass levels after ovariectomy were still comparable to sham operated wild-type mice. Analysis indicated that estrogen depletion increased bone resorption at similar levels in wild type and Shn2 deficient mice though the basal levels of osteoclast number was slightly lower in Shn2-deficient mice. In contrast, basal levels of bone marrow cell mineralization in cultures were low in Shn2-deficeint mice while estrogen depletion increased the mineralization levels to those that were comparable to sham wild type. This indicates that Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss and this correlates with the high levels of mineralization activity in bone marrow cells after ovariectomy. J. Cell. Physiol. 226: 573–578, 2011. © 2010 Wiley-Liss, Inc.
- Subjects :
- medicine.medical_specialty
Physiology
medicine.drug_class
Ovariectomy
Clinical Biochemistry
Osteoclasts
Cell Count
Bone resorption
Bone remodeling
Mice
Calcification, Physiologic
Osteogenesis
Osteoclast
In vivo
Internal medicine
medicine
Animals
Bone Resorption
Luciferases
Enzyme Assays
Mice, Inbred BALB C
Chemistry
Wild type
Organ Size
Cell Biology
DNA-Binding Proteins
medicine.anatomical_structure
Endocrinology
Estrogen
Female
Bone marrow
Cancellous bone
Subjects
Details
- ISSN :
- 00219541
- Volume :
- 226
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....801aa098f920277bc4b984c158d2ed09
- Full Text :
- https://doi.org/10.1002/jcp.22521