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Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy

Authors :
Kazuhisa Nakashima
Hisashi Kurosawa
Yoshitomo Saita
Shunsuke Ishii
Tetsuya Nakamoto
Hiroaki Hemmi
Yoichi Ezura
Ryo Hanyu
Masashi Nagao
Kazuo Kaneko
Tadayoshi Hayata
Takuya Notomi
Masaki Noda
Source :
Journal of Cellular Physiology. 226:573-578
Publication Year :
2010
Publisher :
Wiley, 2010.

Abstract

Schnurri (Shn)-2 is a transcriptional modulator of bone formation and bone resorption and its deficiency causes low turnover state with higher cancellous bone mass due to the defects in osteoclasts that exceeds the defects in osteoblasts in mice. We addressed whether such low turnover of bone remodeling in Shn2 deficiency may be modulated in the absence of estrogen that induces high turnover state in vivo. Ovariectomy reduced bone mass in wild type compared to sham operated control mice and such reduction in bone mass was also observed in Shn2 deficient mice. However, due to the high levels of basal bone mass in Shn2 deficient mice, the bone mass levels after ovariectomy were still comparable to sham operated wild-type mice. Analysis indicated that estrogen depletion increased bone resorption at similar levels in wild type and Shn2 deficient mice though the basal levels of osteoclast number was slightly lower in Shn2-deficient mice. In contrast, basal levels of bone marrow cell mineralization in cultures were low in Shn2-deficeint mice while estrogen depletion increased the mineralization levels to those that were comparable to sham wild type. This indicates that Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss and this correlates with the high levels of mineralization activity in bone marrow cells after ovariectomy. J. Cell. Physiol. 226: 573–578, 2011. © 2010 Wiley-Liss, Inc.

Details

ISSN :
00219541
Volume :
226
Database :
OpenAIRE
Journal :
Journal of Cellular Physiology
Accession number :
edsair.doi.dedup.....801aa098f920277bc4b984c158d2ed09
Full Text :
https://doi.org/10.1002/jcp.22521