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Immune Checkpoint Inhibitor-Associated Myocarditis
- Source :
- JACC Case Reports, JACC: Case Reports, Vol 2, Iss 4, Pp 630-635 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Immune checkpoint inhibitors (ICIs) can induce immunity-related adverse events. We demonstrate the clinical use of cardiac magnetic resonance and endomyocardial biopsy in the diagnosis and subsequent monitoring of ICI-associated myocarditis, suggesting the need to establish and evaluate a cardiac monitoring protocol for patients under ICI therapy. (Level of Difficulty: Intermediate.)<br />Graphical abstract<br />Immune checkpoint inhibitors (ICIs) can induce immunity-related adverse events. We demonstrate the clinical use of cardiac magnetic resonance…
- Subjects :
- 0301 basic medicine
Myocarditis
PD-L, programmed death-ligand
ICI, immune checkpoint inhibitor
RR, reference range
Immune checkpoint inhibitors
medicine.medical_treatment
Case Report
Pembrolizumab
030105 genetics & heredity
Bioinformatics
Endomyocardial biopsy
03 medical and health sciences
0302 clinical medicine
Clinical Case
CMR, cardiac magnetic resonance
NSCLC, non–small cell lung cancer
irAE
LVEF, left ventricular ejection fraction
VT, ventricular tachycardia
polycyclic compounds
medicine
Diseases of the circulatory (Cardiovascular) system
CMR
Adverse effect
LV, left ventricular
LGE, late gadolinium enhancement
business.industry
PD, programmed death
medicine.disease
RC666-701
Non small lung cancer
pembrolizumab
ventricular tachycardia
MMF, mycophenolate mofetil
myocarditis
Cardiac monitoring
Cardiology and Cardiovascular Medicine
Cardiac magnetic resonance
business
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
irAE, immune-related adverse event
Subjects
Details
- ISSN :
- 26660849
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- JACC: Case Reports
- Accession number :
- edsair.doi.dedup.....8025fa589d0f0e8f5d398319cb17f19c
- Full Text :
- https://doi.org/10.1016/j.jaccas.2019.12.047