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Feeding differences in pubertal and aged golden hamsters (Mesocricetus auratus) are related to specific cerebral expression pattern of histamine subtype 3 receptor
- Source :
- Behavioral Neuroscience. 120:1235-1241
- Publication Year :
- 2006
- Publisher :
- American Psychological Association (APA), 2006.
-
Abstract
- The hibernating golden hamster (Mesocricetus auratus) is becoming a useful rodent model to study the neurophysiological role of some neuromediators on vital behaviors such as sleep and thermoregulation. Recent works have shown that the histamine neuroreceptor subtypes (H-sub(1-3)R) are able to modulate such behaviors. Here, specific subtype(s) and cerebral nuclei that were actively operating on feeding behaviors in pubertal and adult hamsters were identified. Of the subtypes assessed, H-sub-3R antagonist (thioperamide) provoked significant (p < .001) changes in behavior (very low total food and water intake) in adults, whereas it did not significantly modify these behaviors in pubertals. The H-sub-3R antagonist's role seemed to be related to elevated amounts of stress-induced damaged neurons displaying, mainly, shrunken crenated cell membranes and altered synaptic processes in limbic areas such as amygdala, cortex, and hippocampus. At the transcription level, an evident expression pattern of H-sub-3R messenger RNA appeared in pubertals, especially in neurons of the cortex and hippocampus, whereas the same trend was featured in amygdalar areas of hibernating adult hamsters, suggesting early H-sub-3R regulatory activities, at least in limbic sites of this rodent model.
- Subjects :
- Male
Aging
medicine.medical_specialty
Central nervous system
Drinking
Hamster
Tritium
Amygdala
Eating
Behavioral Neuroscience
Histamine receptor
chemistry.chemical_compound
Microscopy, Electron, Transmission
Cricetinae
Internal medicine
medicine
Animals
Receptors, Histamine H3
In Situ Hybridization
Analysis of Variance
Thioperamide
Behavior, Animal
Dose-Response Relationship, Drug
Mesocricetus
biology
Age Factors
Brain
Gene Expression Regulation, Developmental
Feeding Behavior
biology.organism_classification
Endocrinology
medicine.anatomical_structure
Animals, Newborn
chemistry
Histamine H1 Antagonists
Neuroscience
Histamine
Protein Binding
medicine.drug
Golden hamster
Subjects
Details
- ISSN :
- 19390084 and 07357044
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Behavioral Neuroscience
- Accession number :
- edsair.doi.dedup.....802cc31be1e1364b9041f55c5900f0b8
- Full Text :
- https://doi.org/10.1037/0735-7044.120.6.1235