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Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome
- Source :
- Nutrients, Nutrients, vol 12, iss 10, Nutrients, Vol 12, Iss 3136, p 3136 (2020), Volume 12, Issue 10
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- A large number of adults and children consume soy in various forms, but little information is available regarding potential neurological side effects. Prior work indicates an association between the consumption of soy-based diets and seizure prevalence in mouse models of neurological disease and in children with autism. Herein, we sought to evaluate potential associations between the consumption of soy-based formula during infancy and disease comorbidities in persons with fragile X syndrome (FXS), while controlling for potentially confounding issues, through a retrospective case-control survey study of participants with FXS enrolled in the Fragile X Online Registry with Accessible Research Database (FORWARD). There was a 25% usage rate of soy-based infant formula in the study population. We found significant associations between the consumption of soy-based infant formula and the comorbidity of autism, gastrointestinal problems (GI) and allergies. Specifically, there was a 1.5-fold higher prevalence of autism, 1.9-fold GI problems and 1.7-fold allergies in participants reporting the use of soy-based infant formula. The major reason for starting soy-based infant formula was GI problems. The average age of seizure and allergy onset occurred long after the use of soy-based infant formula. We conclude that early-life feeding with soy-based infant formula is associated with the development of several disease comorbidities in FXS.
- Subjects :
- Male
Allergy
Pediatrics
Gastrointestinal Diseases
Autism
Disease
Comorbidity
Neurodegenerative
fragile X syndrome (FXS)
soy
0302 clinical medicine
Surveys and Questionnaires
Prevalence
2.1 Biological and endogenous factors
Registries
fragile X syndrome
Infant Nutritional Physiological Phenomena
Pediatric
Nutrition and Dietetics
Confounding
infant formula
Fragile X syndrome
Mental Health
Neurological
Population study
Female
lcsh:Nutrition. Foods and food supply
medicine.medical_specialty
Intellectual and Developmental Disabilities (IDD)
Formulated
autism
lcsh:TX341-641
Article
03 medical and health sciences
Rare Diseases
Food Sciences
Seizures
030225 pediatrics
medicine
Hypersensitivity
Humans
Autistic Disorder
Nutrition
Retrospective Studies
Food, Formulated
business.industry
Neurosciences
Infant
medicine.disease
Brain Disorders
Infant formula
Food
Case-Control Studies
Fragile X Syndrome
Soybeans
business
Digestive Diseases
030217 neurology & neurosurgery
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 12
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....8043e16b37da8e3f423727e5d78da5f7