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Enhanced West Nile Virus Surveillance in a Dengue-Endemic Area—Puerto Rico, 2007

Enhanced West Nile Virus Surveillance in a Dengue-Endemic Area—Puerto Rico, 2007

Authors :
D. Fermin Arguello
Jorge L. Muñoz-Jordán
Manuela Beltran
Elizabeth Hunsperger
Richard Luce
Kay M. Tomashek
Jomil Torres-Aponte
Edgardo Vergne
Enid J. García
Wellington Sun
Publication Year :
2013
Publisher :
The American Society of Tropical Medicine and Hygiene, 2013.

Abstract

In June of 2007, West Nile virus (WNV) was detected in sentinel chickens and blood donors in Puerto Rico, where dengue virus (DENV) is hyperendemic. Enhanced human surveillance for acute febrile illness (AFI) began in eastern Puerto Rico on July 1, 2007. Healthcare providers submitted specimens from AFI cases for WNV and DENV virology and serology testing. Over 6 months, 385 specimens were received from 282 cases; 115 (41%) specimens were DENV laboratory-positive, 86 (31%) specimens were laboratory-indeterminate, and 32 (11%) specimens were laboratory-negative for WNV and DENV. One WNV infection was detected by anti-WNV immunoglobulin M (IgM) antibody and confirmed by a plaque reduction neutralization test. DENV and WNV infections could not be differentiated in 27 cases (10%). During a period of active WNV transmission, enhanced human surveillance identified one case of symptomatic WNV infection. Improved diagnostic methods are needed to allow differentiation of WNV and DENV in dengue-endemic regions.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....80711d4424ee8c25d62da1de1cf80aac