Predictors of intensive care admission in hypoxemic bronchiolitis infants Secondary Analysis of a Randomized Trial

To evaluate in a pre-planned secondary analysis of our parent randomized controlled trial predictors of intensive care admission in infants with bronchiolitis and analyze if these predictors are equally robust for children receiving high-flow or standard-oxygen.A secondary analysis of a multi-center, randomized trial of infants aged12 months with bronchiolitis and an oxygen requirement was performed using admission and outcome data of all 1472 enrolled infants. The primary outcome was intensive care admission. The predictors evaluated were baseline characteristics including physiological data and medical history.Of the 1472 enrolled infants, 146 were admitted to intensive care. Multivariate predictors of intensive care admission were age (weeks) (odds ratio [OR]: 0.98 [95% confidence interval (CI) 0.96-0.99]), pre-enrolment heart rate160/min (OR: 1.80 [95% CI: 1.23-2.63]), pre-enrolment SpOAge2 months, pre-enrolment heart rate160/min, pre-enrolment SpO