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Early versus late MCI: Improved MCI staging using a neuropsychological approach
- Source :
- Alzheimers Dement
- Publication Year :
- 2018
-
Abstract
- Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates "early" and "late" mild cognitive impairment (MCI) based on a single memory test. We compared ADNI's MCI classifications to our neuropsychological approach, which more broadly assesses cognitive abilities. Methods Three hundred thirty-six ADNI-2 participants were classified as "early" or "late" MCI. Cluster analysis was performed on neuropsychological test data, and participants were reclassified based on cluster results. These two staging approaches were compared on progression rates, cerebrospinal fluid biomarkers, and cortical thickness profiles. Results There was little correspondence between the two staging methods. ADNI's early MCI group included a large proportion of false-positive diagnostic errors. The reclassified neuropsychological MCI groups showed steeper survival curves and more abnormal biomarkers. Conclusions Our novel neuropsychological approach improved the staging of MCI by (1) capturing individuals at an early symptomatic stage, (2) minimizing false-positive cases, and (3) identifying a late MCI group further along the disease trajectory.
- Subjects :
- Male
medicine.medical_specialty
Epidemiology
Neuroimaging
Neuropsychological Tests
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Physical medicine and rehabilitation
Developmental Neuroscience
mental disorders
Medicine
Dementia
Cluster Analysis
Humans
Cognitive Dysfunction
Stage (cooking)
Diagnostic Errors
Memory test
Survival analysis
030304 developmental biology
Aged
0303 health sciences
medicine.diagnostic_test
business.industry
Health Policy
Neuropsychology
Cognition
Neuropsychological test
medicine.disease
3. Good health
nervous system diseases
Psychiatry and Mental health
Disease Progression
Female
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 15525279
- Volume :
- 15
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Alzheimer'sdementia : the journal of the Alzheimer's Association
- Accession number :
- edsair.doi.dedup.....807b4b463ae46247330dada10b48732f