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Leukoregulin inhibits the growth of human glioblastoma in vitro
- Source :
- Journal of neuroimmunology. 13(1)
- Publication Year :
- 1986
-
Abstract
- Growth of cultured human glioblastoma cells was profoundly inhibited by concentrated lymphokines prepared from mitogen-activated blood mononuclear cells of normal donors. Cloning efficiency of glioma cells and their absolute number were decreased as well. Partially purified leukoregulin, free of lymphotoxin, tumor necrosis factor and γ-interferon, similarly suppressed DNA synthesis and clonogenicity. The decrease in absolute numbers of tumor target cells indicated that leukoregulin was directly cytolytic as well as cytostatic for human glioblastoma cells. Our data indicate that leukoregulin is at least one of the factors produced by activated lymphocytes which inhibits the proliferation of human glioblastoma in vitro.
- Subjects :
- Lymphokines
Cell growth
Cell Survival
Immunology
Cell Cycle
Lymphokine
Glioma
Biology
medicine.disease
Peripheral blood mononuclear cell
In vitro
Lymphotoxin
Neurology
Cell culture
medicine
Cancer research
Immunology and Allergy
Humans
Tumor necrosis factor alpha
Neurology (clinical)
Cells, Cultured
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....80841c3f2cd943b7ed176d2a8fdee1d9