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Why are ototopical aminoglycosides still first-line therapy for chronic suppurative otitis media? A systematic review and discussion of aminoglycosides versus quinolones
- Source :
- The Journal of laryngology and otology. 130(1)
- Publication Year :
- 2015
-
Abstract
- Objective:This systematic review aimed to establish that quinolones are as effective as aminoglycosides when used to treat chronic suppurative otitis media.Method:The review included good quality, randomised, controlled trials on human subjects, published in English, that compared topical aminoglycosides with topical quinolones for the treatment of chronic suppurative otitis media.Results:Nine trials met the criteria. Two studies showed a higher clinical cure rate in the quinolone group (93 per centvs71 per cent,p= 0.04, and 76 per centvs52 per cent,p= 0.009). Four studies showed no statistically significant difference in clinical outcome. A significant difference in microbiological clearance in favour of quinolones was shown in two studies (88 per centvs30 per cent,p< 0.001, and 88 per centvs30 per cent,p< 0.001).Conclusion:Topical quinolones do not carry the same risk of ototoxicity as aminoglycosides. Furthermore, they are equal or more effective in treating chronic suppurative otitis media and when used as prophylaxis post-myringotomy. Topical quinolones should be considered a first-line treatment for these patients.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Administration, Topical
Chronic Suppurative Otitis Media
Otitis Media, Suppurative
03 medical and health sciences
0302 clinical medicine
Otology
Levofloxacin
030225 pediatrics
Internal medicine
Drug Resistance, Bacterial
medicine
Tobramycin
Humans
030223 otorhinolaryngology
Randomized Controlled Trials as Topic
Postoperative Care
business.industry
General Medicine
Quinolone
Middle Ear Ventilation
Anti-Bacterial Agents
Ciprofloxacin
Otitis
Aminoglycosides
Treatment Outcome
Otorhinolaryngology
Anesthesia
Chronic Disease
Practice Guidelines as Topic
Gentamicin
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 17485460 and 00222151
- Volume :
- 130
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of laryngology and otology
- Accession number :
- edsair.doi.dedup.....80846de33aec82ba04a5eaa3b15fe250