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Hemophagocytic Lymphohistiocytosis in Intensive Care Unit A 71-Case Strobe-Compliant Retrospective Study
- Source :
- Medicine, Medicine, Lippincott, Williams & Wilkins, 2015, 94 (51), pp.7. ⟨10.1097/md.0000000000002318⟩, Medicine, 2015, 94 (51), pp.7. ⟨10.1097/md.0000000000002318⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; Hemophagocytic lymphohistiocytosis (HLH) is a critical condition that may lead to organ failure and early death. The aim of this retrospective observational study was to describe a cohort of HLH patients admitted to intensive care unit (ICU) and investigate the risk factors of early death. A positive HLH diagnosis was defined by an HScore \textgreater= 169. Univariate and multivariate analyses were carried out to investigate hospital and 28-day mortality risk factors. Between January 2002 and July 2014, 71 HLH cases were seen at our institution. The overall 28-day mortality (start at ICU admission) and hospital mortality were 38% and 68%, respectively. The factors associated with increased 28-day mortality were the sequential organ failure assessment score at ICU admission (P \textless .001) and advance in age (P = 0.03). The factors associated with increased hospital mortality were a high sequential organ failure assessment score at ICU admission (P \textless 0.01), advance in age (P = 0.04), and the presence of lymphoma-related HLH or HLH of unknown origin (P \textless 0.01). Organ failure overtops the classical early-death risk factors in adult ICU-admitted HLH patients. This failure and the subsequent early death may be prevented by timely specific cytotoxic therapies and the control of the underlying disease.
- Subjects :
- Adult
Male
endocrine system
medicine.medical_specialty
Organ Dysfunction Scores
[SDV]Life Sciences [q-bio]
Observational Study
Early death
adult patients
Disease
Lymphohistiocytosis, Hemophagocytic
law.invention
Body Temperature
spectrum
law
Risk Factors
hemic and lymphatic diseases
General & Internal Medicine
Medicine
Humans
Hospital Mortality
Intensive care medicine
Critical condition
Aged
Retrospective Studies
Aged, 80 and over
Hemophagocytic lymphohistiocytosis
disease
dysfunction
Adult patients
business.industry
fungi
Age Factors
Retrospective cohort study
General Medicine
Middle Aged
musculoskeletal system
medicine.disease
Intensive care unit
infection
3. Good health
Intensive Care Units
Cohort
Female
business
hormones, hormone substitutes, and hormone antagonists
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 00257974 and 15365964
- Database :
- OpenAIRE
- Journal :
- Medicine, Medicine, Lippincott, Williams & Wilkins, 2015, 94 (51), pp.7. ⟨10.1097/md.0000000000002318⟩, Medicine, 2015, 94 (51), pp.7. ⟨10.1097/md.0000000000002318⟩
- Accession number :
- edsair.doi.dedup.....808e1264960823ade48671b434aebc7a