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Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury

Authors :
Yael Friedman-Levi
Esther Shohami
Sigal Liraz-Zaltsman
S. Thomas Carmichael
Alcino J. Silva
Dana Atrakcy-Baranes
Dalia Shabashov-Stone
Mary T. Joy
Galit Gincberg
Source :
Journal of neurotrauma. 38(14)
Publication Year :
2020

Abstract

Recently, chemokine receptor CC chemokine receptor 5 (CCR5) was found to be a negative modulator of learning and memory. Its inhibition improved outcome after stroke and traumatic brain injury (TBI). To better understand its role after TBI and establish therapeutic strategies, we investigated the effect of reduced CCR5 signaling as a neuroprotective strategy and of the temporal changes of CCR5 expression after TBI in different brain cell types. To silence CCR5 expression

Details

ISSN :
15579042
Volume :
38
Issue :
14
Database :
OpenAIRE
Journal :
Journal of neurotrauma
Accession number :
edsair.doi.dedup.....80a5de1da9ee687fec372683da1c2c5d