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Chemokine Receptors CC Chemokine Receptor 5 and C-X-C Motif Chemokine Receptor 4 Are New Therapeutic Targets for Brain Recovery after Traumatic Brain Injury
- Source :
- Journal of neurotrauma. 38(14)
- Publication Year :
- 2020
-
Abstract
- Recently, chemokine receptor CC chemokine receptor 5 (CCR5) was found to be a negative modulator of learning and memory. Its inhibition improved outcome after stroke and traumatic brain injury (TBI). To better understand its role after TBI and establish therapeutic strategies, we investigated the effect of reduced CCR5 signaling as a neuroprotective strategy and of the temporal changes of CCR5 expression after TBI in different brain cell types. To silence CCR5 expression
- Subjects :
- Male
030506 rehabilitation
Receptors, CXCR4
Time Factors
Receptors, CCR5
Traumatic brain injury
education
Brain recovery
CXCR4
03 medical and health sciences
Chemokine receptor
Mice
0302 clinical medicine
Brain Injuries, Traumatic
medicine
Animals
Stroke
business.industry
Recovery of Function
medicine.disease
Mice, Inbred C57BL
Disease Models, Animal
Cancer research
Neurology (clinical)
0305 other medical science
CC chemokine receptors
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15579042
- Volume :
- 38
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of neurotrauma
- Accession number :
- edsair.doi.dedup.....80a5de1da9ee687fec372683da1c2c5d