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Bugs are not to be silenced: Small RNA pathways and antiviral responses in insects
- Source :
- Annual Review of Virology, Annual Review of Virology, 2016, 3 (1), pp.573-589. ⟨10.1146/annurev-virology-110615-042447⟩, Annual Review of Virology, Annual Review, 2016, 3 (1), pp.573-589. ⟨10.1146/annurev-virology-110615-042447⟩
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- International audience; Like every other organism on Earth, insects are infected with viruses, and they rely on RNA interference (RNAi) mechanisms to circumvent viral infections. A remarkable characteristic of RNAi is that it is both broadly acting, because it is triggered by double-stranded RNA molecules derived from virtually any virus, and extremely specific, because it targets only the particular viral sequence that initiated the process. Reviews covering the different facets of the RNAi antiviral immune response in insects have been published elsewhere. In this review, we build a framework to guide future investigation. We focus on the remaining questions and avenues of research that need to be addressed to move the field forward, including issues such as the activity of viral suppressors of RNAi, comparative genomics, the development of detailed maps of the subcellular localization of viral replication complexes with the RNAi machinery, and the regulation of the antiviral RNAi response.
- Subjects :
- 0301 basic medicine
Small RNA
Small interfering RNA
Insecta
Computational biology
Biology
[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity
Virus
03 medical and health sciences
MESH: RNA, Double-Stranded
RNA interference
small RNAs
Virology
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
MESH: RNA, Small Interfering
Animals
viruses
MESH: Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
RNA, Small Interfering
insects
Organism
RNA, Double-Stranded
Comparative genomics
MESH: Insecta
fungi
RNA
viral suppressors
3. Good health
antiviral immunity
siRNAs
MESH: Virus Diseases
030104 developmental biology
Viral replication
Virus Diseases
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Subjects
Details
- Language :
- English
- ISSN :
- 2327056X and 23270578
- Database :
- OpenAIRE
- Journal :
- Annual Review of Virology, Annual Review of Virology, 2016, 3 (1), pp.573-589. ⟨10.1146/annurev-virology-110615-042447⟩, Annual Review of Virology, Annual Review, 2016, 3 (1), pp.573-589. ⟨10.1146/annurev-virology-110615-042447⟩
- Accession number :
- edsair.doi.dedup.....80ab7e3d6c364d5702e6eef4ee739d2d