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Meta-analysis of studies using statins as a reducer for primary liver cancer risk
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- A protective effect of statins on primary liver cancer (PLC) risk has been suggested. However, issues about the dose–response relationship, the protective effect of individual statins and PLC risk reduction among at-risk populations remain unsolved. Therefore, a meta-analysis was conducted. PubMed and EMBASE were searched for studies providing the risk ratio (RR) on statins and PLC risk. Summary RRs were calculated using a random-effects model. Twenty-five studies were identified. Stain use was significantly associated with a reduced risk of PLC (RR = 0.60, 95% confidence interval (CI) = 0.53–0.69). The summary RR for every additional 50 cumulative defined daily doses per year was 0.87 (95% CI = 0.83–0.91). Evidence of a non-linear dose–response relationship between statins and PLC risk was found (Pnon-linearity Pinteraction = 0.02). Overall, these findings add to our understanding of the association between statins and PLC risk. Whether statin use is causally associated with a reduced risk of PLC should be further studied.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Reduced risk
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Odds Ratio
medicine
Humans
Rosuvastatin
Multidisciplinary
Dose-Response Relationship, Drug
business.industry
Liver Neoplasms
nutritional and metabolic diseases
Odds ratio
Statin treatment
Confidence interval
Surgery
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
Relative risk
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Primary liver cancer
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....80c268df01596325fe72285cd10d5f37
- Full Text :
- https://doi.org/10.1038/srep26256