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Gut microbiota and bone metabolism
- Source :
- The FASEB Journal. 35
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Osteoporosis is the most common metabolic skeletal disease. It is characterized by the deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even bone fractures. Accumulating evidence has indicated that there is an inextricable relationship between the gut microbiota (GM) and bone homeostasis involving host-microbiota crosstalk. Any perturbation of the GM can play an initiating and reinforcing role in disrupting the bone remodeling balance during the development of osteoporosis. Although the GM is known to influence bone metabolism, the mechanisms associated with these effects remain unclear. Herein, we review the current knowledge of how the GM affects bone metabolism in health and disease, summarize the correlation between pathogen-associated molecular patterns of GM structural components and bone metabolism, and discuss the potential mechanisms underlying how GM metabolites regulate bone turnover. Deciphering the complicated relationship between the GM and bone health will provide new insights into the prevention and treatment of osteoporosis.
- Subjects :
- 0301 basic medicine
Osteoporosis
Disease
Biology
Gut flora
Bioinformatics
Biochemistry
Bone health
Bone and Bones
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Genetics
medicine
Animals
Homeostasis
Humans
Molecular Biology
Pathogen-associated molecular pattern
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Crosstalk (biology)
030104 developmental biology
Bone Remodeling
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- ISSN :
- 15306860 and 08926638
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- The FASEB Journal
- Accession number :
- edsair.doi.dedup.....80c6223d85b27d7cb85e2eeb2430e94f