Back to Search
Start Over
Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry
Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry
- Source :
- ResearcherID
- Publisher :
- Cell Press.
-
Abstract
- Signaling molecules such as Activin, Sonic hedgehog, Nodal, Lefty, and Vg1 have been found to be involved in determination of left-right (L-R) asymmetry in the chick, mouse, or frog. However, a common signaling pathway has not yet been identified in vertebrates. We report that Pitx2, a bicoid-type homeobox gene expressed asymmetrically in the left lateral plate mesoderm, may be involved in determination of L-R asymmetry in both mouse and chick. Since Pitx2 appears to be downstream of lefty-1 in the mouse pathway, we examined whether mouse Lefty proteins could affect the expression of Pitx2 in the chick. Our results indicate that a common pathway from lefty-1 to Pitx2 likely exists for determination of L-R asymmetry in vertebrates.
- Subjects :
- animal structures
Left-Right Determination Factors
Chick Embryo
Biology
General Biochemistry, Genetics and Molecular Biology
Mice
stomatognathic system
Transforming Growth Factor beta
Animals
Drosophila Proteins
Paired Box Transcription Factors
Hedgehog Proteins
Heart looping
Sonic hedgehog
Body Patterning
Homeodomain Proteins
Genetics
Models, Genetic
PITX2
Biochemistry, Genetics and Molecular Biology(all)
Lateral plate mesoderm
Genes, Homeobox
Gene Expression Regulation, Developmental
Nuclear Proteins
Proteins
Lefty
Embryo, Mammalian
Cell biology
stomatognathic diseases
Protein Biosynthesis
embryonic structures
Trans-Activators
biology.protein
Homeobox
NODAL
Signal Transduction
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 00928674
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....80cafa3c85054defc7cd7d1ecc9ff19a
- Full Text :
- https://doi.org/10.1016/S0092-8674(00)81473-7