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Triterpenoids with antimicrobial activity from Drypetes inaequalis

Triterpenoids with antimicrobial activity from Drypetes inaequalis

Authors :
Marlise Diane J. Dongfack
Philippe Vérité
Sabrina Boutefnouchet
Guy Merlin Nguenang
Francois Tillequin
Jovita Chi Shirri
Zacharias Tanee Fomum
Elisabeth Seguin
Simon Suh Awanchiri
Hanh Trinh-Van-Dufat
Jean Wandji
Source :
Phytochemistry. 70:419-423
Publication Year :
2009
Publisher :
Elsevier BV, 2009.

Abstract

The air-dried stems and ripe fruit of Drypetes inaequalis Hutch. (Euphorbiaceae) were studied. Four triterpene derivatives, characterized as lup-20(29)-en-3beta,6alpha-diol, 3beta-acetoxylup-20(29)-en-6alpha-ol, 3beta-caffeoyloxylup-20(29)-en-6alpha-ol and 28-betad-glucopyranosyl-30-methyl 3beta-hydroxyolean-12-en-28,30-dioate along with 10 known compounds were isolated from the whole stems. One triterpene, characterized as 3alpha-hydroxyfriedelan-25-al along with six known compounds were isolated from the ripe fruit. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The triterpenes were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and two of them appeared to be modestly active.

Details

ISSN :
00319422
Volume :
70
Database :
OpenAIRE
Journal :
Phytochemistry
Accession number :
edsair.doi.dedup.....80efca39475c30dd24597d264c011bf9
Full Text :
https://doi.org/10.1016/j.phytochem.2008.12.017