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Brain perfusion SPECT imaging and acetazolamide challenge in vascular cognitive impairment
- Source :
- Nuclear Medicine Communications, Nuclear Medicine Communications, Lippincott, Williams & Wilkins, 2012, 33 (6), pp.571-580. ⟨10.1097/MNM.0b013e328351d583⟩
- Publication Year :
- 2012
- Publisher :
- HAL CCSD, 2012.
-
Abstract
- International audience; Cerebrovascular disease is recognized as a common cause of cognitive impairment and dementia, alone or coexisting with other neurodegenerative diseases, mostly Alzheimer's disease. Vascular cognitive impairment (VCI) is a part of the heterogenous disorders group related to cerebral vessel disease. Although age is one of the most important risk factors for VCI, other common cardiovascular risk factors are also involved. By investigating these risk factors, a high proportion of these cognitive disorders can be prevented and/or delayed. Until now, only treatment of rnidlife arterial hypertension has been recognized as a preventing factor of vascular dementia. Brain MRI is becoming the method of choice to investigate cerebral vascular pathologies. However, this form of morphological imaging remains inadequate and does not provide useful functional information during VCI exploration, despite which functional imaging such as brain perfusion single-photon computed tomography, performed in baseline conditions and/or after an acetazolamide challenge, is underutilized in VCI exploration. The common strategies for VCI screening have not been standardized until now, and therefore further long-term imaging studies are needed to establish early diagnostic protocols. The present review summarizes the potential benefits of brain perfusion single-photon computed tomography imaging and possible scintigraphic quantification of cerebral hemodynamic reserves in investigation of VCI. Nucl Med Commun 33:571-580 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
- Subjects :
- cardiovascular risk factors
[SDV]Life Sciences [q-bio]
EMISSION COMPUTED-TOMOGRAPHY
Perfusion scanning
brain imaging
Disease
030218 nuclear medicine & medical imaging
0302 clinical medicine
SMALL VESSEL DISEASE
Risk Factors
HYPERTENSIVE PATIENTS
WHITE-MATTER HYPERINTENSITIES
Carbonic Anhydrase Inhibitors
functional imaging
Brain
CEREBROVASCULAR REACTIVITY
Cognition
General Medicine
Magnetic Resonance Imaging
3. Good health
ALZHEIMERS-DISEASE
Cardiology
Acetazolamide
medicine.drug
medicine.medical_specialty
dysexecutive syndrome
03 medical and health sciences
Internal medicine
Spect imaging
medicine
Dementia
Humans
Radiology, Nuclear Medicine and imaging
Vascular dementia
vascular cognitive impairment
Tomography, Emission-Computed, Single-Photon
business.industry
vascular dementia
FRONTOTEMPORAL DEMENTIA
medicine.disease
Functional imaging
Cerebrovascular Disorders
brain perfusion single-photon computed tomography
CEREBRAL-BLOOD-FLOW
RISK-FACTORS
SUBCORTICAL DEMENTIAS
business
Cognition Disorders
Tomography, X-Ray Computed
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 01433636
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine Communications, Nuclear Medicine Communications, Lippincott, Williams & Wilkins, 2012, 33 (6), pp.571-580. ⟨10.1097/MNM.0b013e328351d583⟩
- Accession number :
- edsair.doi.dedup.....811cc6718b2b7ea564c6b7a2e857491d