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Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats
- Source :
- Molecular Nutrition & Food Research. 61:1600418
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- cope Virgin olive oil is an essential component of the Mediterranean diet. Its antioxidant and anti-inflammatory properties are mainly linked to phenolic contents. This study aims to evaluate the beneficial effects of a polyphenol-rich virgin olive oil (HPCOO) or olive oil without polyphenols (WPOO) in rats fed high-fat diet (HFD). Methods and results Male Sprague-Dawley rats were divided into four groups based on the different types of diet: (I) standard diet (STD); (II) HFD; (III) HFD containing WPOO, and (IV) HFD containing HPCOO. HPCOO and WPOO induced a significant improvement of HFD-induced impaired glucose homeostasis (by hyperglycemia, altered oral glucose tolerance, and HOMA-IR) and inflammatory status modulating pro- and anti-inflammatory cytokines (TNF-α, IL-1, and IL-10) and adipokines. Moreover, HPCOO and less extensively WPOO, limited HFD-induced liver oxidative and nitrosative stress and increased hepatic fatty acid oxidation. To study mitochondrial performance, oxidative capacity and energy efficiency were also evaluated in isolated liver mitochondria. HPCOO, but not WPOO, reduced H2O2 release and aconitase activity by decreasing degree of coupling, which plays a major role in the control of mitochondrial reactive oxygen species emission. Conclusion HPCOO limits HFD-induced insulin resistance, inflammation, and hepatic oxidative stress, preventing nonalcoholic fatty liver disease progression.
- Subjects :
- Male
0301 basic medicine
Antioxidant
Mediterranean diet
medicine.medical_treatment
Tocopherols
Mitochondria, Liver
Mitochondrion
medicine.disease_cause
Hepatitis
Rats, Sprague-Dawley
Inflammation, Mediterranean diet, hepatic oxidative stress, Nonalcoholic Fatty liver disease, Olive oil polyphenols, Adipokines, Animals, Cytokines, Diet, High-Fat, Disease Models, Animal, Lipid Metabolism, Polyphenols, Rats, Sprague-Dawley, Tocopherols, Insulin Resistance
0302 clinical medicine
Nonalcoholic fatty liver disease
Glucose homeostasis
Beta oxidation
food and beverages
Olive oil polyphenols
030220 oncology & carcinogenesis
Cytokines
Biotechnology
medicine.medical_specialty
Biology
Diet, High-Fat
03 medical and health sciences
Insulin resistance
Adipokines
Internal medicine
medicine
Animals
Olive Oil
Inflammation
Animal
hepatic oxidative stress
Polyphenols
Non-alcoholic Fatty liver disease
Lipid Metabolism
medicine.disease
Mitochondrial and hepatic oxidative stre
Diet
Rats
High-Fat
Disease Models, Animal
Oxidative Stress
Glucose
030104 developmental biology
Endocrinology
Nonalcoholic Fatty liver disease
Disease Models
Sprague-Dawley
Insulin Resistance
Oxidative stress
Food Science
Subjects
Details
- ISSN :
- 16134125
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Molecular Nutrition & Food Research
- Accession number :
- edsair.doi.dedup.....81269cafbb2d90761981cfa106240ac6