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Identical TP53 mutations in pelvic carcinosarcomas and associated serous tubal intraepithelial carcinomas provide evidence of their clonal relationship
- Source :
- Virchows Archiv. 469:61-69
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Pelvic carcinosarcomas (PCSs) are rare aggressive biphasic tumors that localize in the ovary, fallopian tube, or peritoneum and present frequently as bilateral disease. We undertook a morphological, p53 immunohistochemical and TP53 gene mutational analysis study in a single institution cohort of 16 PCSs in order to investigate the nature of bilateral tumors and to shed light on their origin and pathogenesis. Of the 16 patients, 10 presented with bilateral disease, 6 with a carcinosarcoma in both adnexa, and the remaining cases with a carcinosarcoma in one adnexum and a carcinoma in the opposite. The carcinoma component showed high-grade serous features in 13/16 of cases (81 %). In 10 patients (63 %), a serous tubal intraepithelial carcinoma (STIC) was found, in one case bilateral, making a total of 11 STICs. STIC was found only in cases with a carcinoma component with high-grade serous features. All 10 bilateral tumors and all 11 PCS-associated STICs showed a similar p53 immunostaining pattern. At mutation analysis of the TP53 gene, all five bilateral PCS contained an identical mutation in both localizations. Furthermore, a TP53 mutation was found in 8 of 10 STICs, with an identical mutation in the associated PCS. The finding of similar p53 immunostaining in all bilateral cases and identical TP53 mutations in most PCS-associated STIC provides evidence for a clonal relation between these neoplastic lesions, supporting a metastatic nature of bilateral PCS and suggesting that they have an extraovarian origin in a STIC.
- Subjects :
- p53
0301 basic medicine
Pathology
medicine.medical_specialty
Cystadenocarcinoma
Bilateral
Carcinosarcoma
STIC
TP53
Aged
Carcinoma in Situ
Cystadenocarcinoma, Serous
Female
Genes, p53
Humans
Immunohistochemistry
Middle Aged
Mutation
Ovarian Neoplasms
Pelvic Neoplasms
Precancerous Conditions
2734
Molecular Biology
Cell Biology
Biology
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Peritoneum
medicine
Carcinoma
Carcinoma in situ
Serous
Serous Tubal Intraepithelial Carcinoma
General Medicine
medicine.disease
Serous fluid
030104 developmental biology
medicine.anatomical_structure
Genes
030220 oncology & carcinogenesis
Fallopian tube
Subjects
Details
- ISSN :
- 14322307 and 09456317
- Volume :
- 469
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi.dedup.....8149493a2f77153631023b56b5e4a987