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Urinary Soluble CD163 Levels Predict IgA Nephropathy Remission Status
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2021
-
Abstract
- Noninvasive biomarkers of disease activity are needed to predict disease remission status in patients with IgA nephropathy (IgAN). Soluble CD163 (sCD163), shed by monocytes and macrophages, is a potential biomarker in diseases associated with excessive macrophage activation. We investigated the association of urinary sCD163 (u-sCD163) with histopathological activity and clinical manifestations in 349 patients with biopsy-diagnosed IgAN. U-sCD163 was measured via enzyme-linked immunosorbent assay. In patients with IgAN, higher u-sCD163 levels were associated with histological lesions of greater severity, as well as more proteinuria and poorer renal function. Additionally, u-sCD163 was correlated with infiltration of tubulointerstitial CD163+ macrophages. High u-sCD163 levels (>3.57 ng/mg Cr) were associated with a 2.66-fold greater risk for IgAN remission failure in adjusted analyses. Adding u-sCD163 levels to the model containing clinical data at biopsy and MEST-C score significantly improved the risk prediction of IgAN remission status (AUC 0.788). Together, our results suggest that u-sCD163 may be a useful noninvasive biomarker to evaluate disease severity and remission status of IgAN.
- Subjects :
- Adult
Male
Remission, Spontaneous
Immunology
Antigens, Differentiation, Myelomonocytic
Receptors, Cell Surface
urologic and male genital diseases
Kidney
Severity of Illness Index
urinary soluble CD163
Antigens, CD
Predictive Value of Tests
Immunology and Allergy
Humans
Retrospective Studies
Original Research
Macrophages
Glomerulonephritis, IGA
IgA nephropathy
RC581-607
Middle Aged
Prognosis
Solubility
remission status
biomarker
Female
Immunologic diseases. Allergy
Biomarkers
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.doi.dedup.....81526aec639770ec969b7a739e199a06