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A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases
- Source :
- Cells, Vol 10, Iss 823, p 823 (2021), Cells, Volume 10, Issue 4
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones of the human gut ecosystem and to prevent adipogenesis. The objectives of the present study were to demonstrate the antiobesity potential of a new strain of Christensenella minuta in preclinical models and explore related mechanisms of action. The antiobesity potential of C. minuta DSM33407 was assessed in a diet-induced obesity mouse model. Changes in hepatic lipid metabolism were explored using targeted transcriptomics. Effects on gut microbiota were further assessed in a humanized Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model inoculated with obese fecal samples. Shotgun metagenomics was applied to study microbial community structures in both models. C. minuta DSM33407 protected from diet-induced obesity and regulated associated metabolic markers such as glycemia and leptin. It also regulated hepatic lipid metabolism through a strong inhibition of de novo lipogenesis and maintained gut epithelial integrity. In the humanized SHIME® model, these effects were associated with modulations of the intestinal microbiota characterized by a decreased Firmicutes/Bacteroidetes ratio. These data indicate that C. minuta DSM33407 is a convincing therapeutic candidate for the management of obesity and associated metabolic disorders.
- Subjects :
- Male
0301 basic medicine
obesity
Firmicutes
microbiome
Gut flora
Article
Microbiology
Feces
03 medical and health sciences
0302 clinical medicine
Metabolic Diseases
medicine
Animals
Humans
metabolic disorders
Microbiome
lcsh:QH301-705.5
Phylogeny
Clostridiales
biology
Leptin
Bacteroidetes
Epithelial Cells
Biodiversity
General Medicine
Lipid Metabolism
biology.organism_classification
medicine.disease
Diet
Gastrointestinal Microbiome
Biological Therapy
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
Liver
lcsh:Biology (General)
Adipogenesis
Lipogenesis
030211 gastroenterology & hepatology
Dysbiosis
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 823
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....816df3c7c0dd89f178bb11862d5ab2fb