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Changes of inflammatory mediators and oxidative stress indicators in children with Henoch-Schönlein purpura and clinical effects of hemoperfusion in the treatment of severe Henoch-Schönlein purpura with gastrointestinal involvement in children
- Source :
- BMC Pediatrics, Vol 19, Iss 1, Pp 1-10 (2019), BMC Pediatrics
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background To explore the changes of inflammatory and oxidative stress responses in Henoch-Schönlein purpura (HSP) children, and further analyzed the therapeutic effects and mechanisms of hemoperfusion (HP) on HSP with severe gastrointestinal (GI) involvement. Methods There were 200 children with HSP were divided into three groups according to their clinical manifestations: 60 in HSP without GI and renal involvement group, 60 in HSP with GI involvement group, and 80 in HSPN group. The HSP with GI involvement group was subdivided into conventional treatment (n = 30) and HP (n = 30) groups. Thirty children who visited the department of children healthcare for healthy physical examinations from January to December 2017 were set as healthy control group. The IL-6 and TNF-α levels were detected by chemoluminescence method. The MDA, SOD and T-AOC levels were determined by thiobarbituric acid colorimetric method, hydroxylamine method and chemical colorimetry. Results Compared with healthy group, IL-6, TNF-α and MDA levels in HSP were increased in each group, while SOD and T-AOC were decreased (P = 0.000). IL-6, TNF-α and MDA levels in the HSPN group were the highest, SOD and T-AOC levels were the lowest (P = 0.000). Compared with those before treatment, IL-6, TNF-α and MDA levels in the conventional and HP groups were decreased and SOD and T-AOC levels were increased (P = 0.000). The changes in HP group were more significant than those in conventional group (P P = 0.000, 0.004). Conclusions Inflammatory and oxidative stress may be involved in the acute phase of HSP children. The intensity of inflammatory and oxidative stress responses were related to the degree of renal involvement. HP can reduce glucocorticoid dosage and the rate of renal involvement in children with severe HSP with GI involvement. The mechanism may be related to the fact that HP can effectively remove IL-6, TNF-α, MDA in HSP children.
- Subjects :
- Male
Henoch-Schonlein purpura
Thiobarbituric acid
medicine.medical_treatment
Angiotensin-Converting Enzyme Inhibitors
medicine.disease_cause
Kidney
Gastroenterology
chemistry.chemical_compound
0302 clinical medicine
Medicine
030212 general & internal medicine
Child
Children
Proteinuria
lcsh:RJ1-570
Hemoperfusion
Inflammatory mediators
Henoch-Schönlein purpura
Purpura
Child, Preschool
Female
medicine.symptom
Inflammation Mediators
Glucocorticoid
Immunosuppressive Agents
medicine.drug
Research Article
medicine.medical_specialty
Adolescent
IgA Vasculitis
Methylprednisolone
03 medical and health sciences
Angiotensin Receptor Antagonists
Internal medicine
Humans
Glucocorticoids
030203 arthritis & rheumatology
business.industry
Interleukin-6
Superoxide Dismutase
Tumor Necrosis Factor-alpha
Therapeutic effect
lcsh:Pediatrics
medicine.disease
Intestinal Diseases
chemistry
Oxidative stress
Case-Control Studies
Pediatrics, Perinatology and Child Health
Lipid Peroxidation
business
Subjects
Details
- Language :
- English
- ISSN :
- 14712431
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Pediatrics
- Accession number :
- edsair.doi.dedup.....817f9e640c3eba1650901bc93a853564