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Sulindac and indomethacin suppress the diuretic action of furosemide in patients with cirrhosis and ascites: evidence that sulindac affects renal prostaglandins
- Publication Year :
- 1985
-
Abstract
- Nonsteroidal anti-inflammatory drugs (NSAID) suppress prostaglandin-dependent renal blood flow and furosemide-induced diuresis in patients with cirrhosis and ascites. Since sulindac may selectively spare inhibition of renal prostaglandins, we evaluated the interactions of acute administration of sulindac or indomethacin with furosemide in 15 patients with cirrhosis and ascites. Prior to furosemide, indomethacin reduced creatinine clearance (by 55%), urinary volume (by 82%), sodium (by 93%), and prostaglandin E2 (by 87%) (all P less than 0.05), whereas sulindac had no effect. However, both drugs reduced furosemide-induced diuresis. Indomethacin appeared slightly more potent in reducing the diuresis (55% v 38%), natriuresis (67% v 52%), and prostaglandin E2 (PGE2) release (81% v 74%). In a similar protocol in healthy subjects, furosemide-induced diuresis and natriuresis were also blunted by both drugs. Thus, under conditions of enhanced prostaglandin activity from furosemide, sulindac does affect renal function. These data suggest that renal function should be monitored in patients with cirrhosis and ascites who receive sulindac as well as other NSAID. Am J Kidney Dis
- Subjects :
- Liver Cirrhosis
medicine.medical_treatment
Indomethacin
Anti-Inflammatory Agents
Pharmacology
Diuresis/drug effects
chemistry.chemical_compound
Sulindac
Furosemide
Creatinine/urine
Prostaglandin Antagonists/pharmacology
Ascites
Sodium/urine
Medicine
Anti-Inflammatory Agents/pharmacology
Clinical Trials as Topic
Indenes/*pharmacology
Prostaglandin antagonist
Sulindac/*pharmacology
Indenes
Nephrology
Creatinine
medicine.symptom
Furosemide/*antagonists & inhibitors
medicine.drug
Prostaglandin Antagonists
Natriuresis
Diuresis
Dinoprostone
Indomethacin/therapeutic use
Humans
Prostaglandins E/urine
Liver Cirrhosis/*drug therapy/urine
business.industry
Prostaglandins E
Sodium
digestive system diseases
Ascites/drug therapy/urine
Potassium/urine
chemistry
Renal blood flow
Potassium
Natriuresis/drug effects
Drug Evaluation
Diuretic
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....81817fe952e05681b0da8c74869df6c2