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Coronary heart disease in mothers and fathers of adult children with alcohol use disorders

Coronary heart disease in mothers and fathers of adult children with alcohol use disorders

Authors :
Henrik Ohlsson
Jan Sundquist
Kenneth S. Kendler
Susanna Calling
Kristina Sundquist
Source :
Addiction. 116:3390-3397
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

BACKGROUND AND AIM: Having a family member with an alcohol use disorder (AUD) may negatively affect a person's health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD. DESIGN: Cohort study. Cox regression models and co-sibling analyses. PARTICIPANTS: From population registers, we selected all parent-offspring pairs in which the parent was born in Sweden between 1945 and 1965. MEASUREMENTS: Baseline was set when the offspring was 15 years old and AUD was assessed from medical and criminal registers. The parents were followed for CHD during a mean follow-up of 18 years. Hazard ratios (HRs) in mothers and fathers were calculated and adjusted for potential confounders (year of birth, age at childbirth, sex of the child, parent's AUD, educational level and marital status). FINDINGS: In mothers, the adjusted HR for CHD was 1.24 (95% confidence interval [CI]: 1.19-1.28) in relation to having a child with AUD. In fathers, the HR for CHD was lower than in mothers but still increased; the adjusted HR was 1.08 (95% CI: 1.05-1.12). In the co-sibling analyses, the HRs for mothers were similar to the HRs estimated from the population-based sample, but in fathers the association did not remain significant (HR 0.98 [0.90-1.06]). CONCLUSIONS: In Sweden there appears to be an association between having an offspring with alcohol use disorder and increased risk of developing coronary heart disease. For fathers, the association did not remain in co-sibling analyses.

Details

ISSN :
13600443 and 09652140
Volume :
116
Database :
OpenAIRE
Journal :
Addiction
Accession number :
edsair.doi.dedup.....81aa374b3c7741c46ed625f4d9092e93
Full Text :
https://doi.org/10.1111/add.15591