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Coronary heart disease in mothers and fathers of adult children with alcohol use disorders
Coronary heart disease in mothers and fathers of adult children with alcohol use disorders
- Source :
- Addiction. 116:3390-3397
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- BACKGROUND AND AIM: Having a family member with an alcohol use disorder (AUD) may negatively affect a person's health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD. DESIGN: Cohort study. Cox regression models and co-sibling analyses. PARTICIPANTS: From population registers, we selected all parent-offspring pairs in which the parent was born in Sweden between 1945 and 1965. MEASUREMENTS: Baseline was set when the offspring was 15 years old and AUD was assessed from medical and criminal registers. The parents were followed for CHD during a mean follow-up of 18 years. Hazard ratios (HRs) in mothers and fathers were calculated and adjusted for potential confounders (year of birth, age at childbirth, sex of the child, parent's AUD, educational level and marital status). FINDINGS: In mothers, the adjusted HR for CHD was 1.24 (95% confidence interval [CI]: 1.19-1.28) in relation to having a child with AUD. In fathers, the HR for CHD was lower than in mothers but still increased; the adjusted HR was 1.08 (95% CI: 1.05-1.12). In the co-sibling analyses, the HRs for mothers were similar to the HRs estimated from the population-based sample, but in fathers the association did not remain significant (HR 0.98 [0.90-1.06]). CONCLUSIONS: In Sweden there appears to be an association between having an offspring with alcohol use disorder and increased risk of developing coronary heart disease. For fathers, the association did not remain in co-sibling analyses.
- Subjects :
- Adolescent
Offspring
Population
Mothers
030508 substance abuse
Medicine (miscellaneous)
Coronary Disease
Alcohol use disorder
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Humans
Medicine
Registries
030212 general & internal medicine
education
Sweden
education.field_of_study
business.industry
Proportional hazards model
Hazard ratio
medicine.disease
Confidence interval
Alcoholism
Psychiatry and Mental health
Adult Children
Marital status
Female
0305 other medical science
business
Demography
Cohort study
Subjects
Details
- ISSN :
- 13600443 and 09652140
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- Addiction
- Accession number :
- edsair.doi.dedup.....81aa374b3c7741c46ed625f4d9092e93
- Full Text :
- https://doi.org/10.1111/add.15591