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Panācancer analysis of iron metabolic landscape across the Cancer Genome Atlas
- Source :
- Journal of Cellular Physiology. 235:1013-1024
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Iron is an essential metal ion in the human body and usually dysregulated in cancers. However, a comprehensive overview of the iron-related genes and their clinical relevance in cancer is lacking. In this study, we utilized the expression profiling, proteomics, and epigenetics from the Cancer Genome Atlas database to systematically characterized the alterations of iron-related genes. There were multiple iron-related genes with dysregulation across 14 cancers and some of these ectopic changes may be associated with aberrant DNA methylation. Meanwhile, a variety of genes were significantly associated with patient survival, especially in kidney renal clear cell carcinoma. Then differentially expressed genes were validated in clinical samples. Finally, we found deferoxamine and erastin could inhibit proliferation in various tumor cells and influence the expression of several iron-related genes. Overall, our study provides a comprehensive analysis of iron metabolism across cancers and highlights the potential treatment of iron targeted therapies for cancers.
- Subjects :
- 0301 basic medicine
Cell Survival
Physiology
Iron
Clinical Biochemistry
Biology
Proteomics
Epigenesis, Genetic
03 medical and health sciences
0302 clinical medicine
Databases, Genetic
Biomarkers, Tumor
medicine
Humans
Clinical significance
Epigenetics
Gene
Kidney
Gene Expression Profiling
Cell Biology
Gene Expression Regulation, Neoplastic
Gene expression profiling
Deferoxamine
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
DNA methylation
Cancer research
medicine.drug
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 235
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....81af5dcdfd1391264c8fd6ac314e115c